I-Plozasiran

Incazelo emfushane:

I-Plozasiran API i-RNA encane ephazamisayo yokwenziwa (i-siRNA) eyenzelwe ukwelapha i-hypertriglyceridemia kanye nokuphazamiseka kwenhliziyo nemithambo yegazi okuhlobene. Ihlose iI-APOC3I-gene, ehlanganisa i-apolipoprotein C-III, isilawuli esiyinhloko se-triglyceride metabolism. Ocwaningweni, i-Plozasiran isetshenziselwa ukutadisha amasu okwehlisa i-lipid asuselwa ku-RNAi, ukucaciswa kokuthulisa izakhi zofuzo, kanye nokwelashwa okuthatha isikhathi eside ezimeni ezifana ne-familia chylomicronemia syndrome (FCS) kanye ne-dyslipidemia exubile.

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Omaka bomkhiqizo

I-Plozasiran (API)

Isicelo socwaningo:
I-Plozasiran API i-RNA encane ephazamisayo yokwenziwa (i-siRNA) eyenzelwe ukwelapha i-hypertriglyceridemia kanye nokuphazamiseka kwenhliziyo nemithambo yegazi okuhlobene. Ihlose iI-APOC3I-gene, ehlanganisa i-apolipoprotein C-III, isilawuli esiyinhloko se-triglyceride metabolism. Ocwaningweni, i-Plozasiran isetshenziselwa ukutadisha amasu okwehlisa i-lipid asuselwa ku-RNAi, ukucaciswa kokuthulisa izakhi zofuzo, kanye nokwelashwa okuthatha isikhathi eside ezimeni ezifana ne-familia chylomicronemia syndrome (FCS) kanye ne-dyslipidemia exubile.

Umsebenzi:
I-Plozasiran isebenza ngokuthulisaI-APOC3i-mRNA esibindini, okuholela ekwehleni kwamazinga e-apolipoprotein C-III. Lokhu kuthuthukisa i-lipolysis ethuthukisiwe kanye nokucaciswa kwe-triglyceride-rich lipoprotein egazini. Njenge-API, i-Plozasiran inika amandla ukuthuthukiswa kwezindlela zokwelapha ezithatha isikhathi eside okuhloswe ngazo ukwehlisa ngokuphawulekayo amazinga e-triglyceride kanye nokunciphisa ingozi ye-pancreatitis kanye nezenzakalo zenhliziyo nemithambo yegazi ezigulini ezinezinkinga ezinzima noma zofuzo ze-lipid.

Okwedlule: Givosiran

Olandelayo: Zilebesiran

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