Pharma Izithako
-
I-Fmoc-Ls(Pal-Glu-OtBu)-OH
I-Fmoc-Ls(Pal-Glu-OtBu)-OH iyibhulokhi elikhethekile lokwakha i-amino acid elakhelwe ukuhlangana kwe-peptide-lipid. Ifaka i-lysine evikelwe nge-Fmoc enochungechunge oluseceleni lwe-palmitoyl-glutamate, ethuthukisa ukuhlangana kwe-membrane kanye nokuba khona kwe-bioavailability.
-
Fmoc-His-Aib-OH
I-Fmoc-His-Aib-OH iyibhulokhi yokwakha ye-dipeptide esetshenziswa ekuhlanganiseni kwe-peptide, ehlanganisa i-Fmoc-protected histidine ne-Aib (α-aminoisobutyric acid). I-Aib yethula ukuqina kwe-conformational, ikwenze kube wusizo ekuklameni ama-peptide e-helical nezinzile.
-
I-Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH
I-Boc-His(Trt)-Aib-Glu(OtBu)-Gly-OH iyingxenye evikelwe ye-tetrapeptide esetshenziswa ekuhlanganiseni kwe-peptide nokuthuthukiswa kwezidakamizwa. Iqukethe amaqembu asebenzayo avikelwe ngendlela ehlelekile ukuze kuhlanganiswe isinyathelo futhi ifake i-Aib (α-aminoisobutyric acid) ukuze kuthuthukiswe ukuqina kwe-helix kanye nokuqina kwe-conformational.
-
I-Ste-γ-Glu-AEEA-AEEA-OSU
I-Ste-γ-Glu-AEEA-AEEA-OSU iyingqamuzana yokwenziwa ye-lipidated linker eyenzelwe ukulethwa kwezidakamizwa okuhlosiwe kanye nama-antibody–drug conjugates (ADCs). Ifaka umsila we-stearoyl (Ste) we-hydrophobic, i-γ-glutamyl eqondiwe motif, izikhala ze-AEEA zokuguquguquka, kanye neqembu le-OSu (NHS ester) lokuhlanganisa kahle.
-
Fmoc-Ile-αMeLeu-Leu-OH
I-Fmoc-Ile-αMeLeu-Leu-OH iyisakhiwo sokwenziwa esivikelwe se-tripeptide esine-α-methylated leucine, evame ukusetshenziswa ekwakhiweni kwezidakamizwa ze-peptide ukuze kuthuthukiswe ukuzinza kwe-metabolic kanye nokukhetha kwe-receptor.
-
I-Dodecyl Phosphocholine (DPC)
I-Dodecyl Phosphocholine (DPC) isihlanzi sokwenziwa se-zwitterionic esisetshenziswa kakhulu ocwaningweni lwamaprotheni e-membrane kanye ne-structural biology, ikakhulukazi ku-NMR spectroscopy kanye ne-crystallography.
-
I-Donidalorsen
I-Donilorsen API iyi-antisense oligonucleotide (ASO) ephenywayo yokwelashwa kwe-angioedema yofuzo (HAE) kanye nezimo zokuvuvukala ezihlobene. Kufundwa kumongo wezindlela zokwelapha eziqondiswe ku-RNA, okuhloswe ngazo ukunciphisa ukubonakaliswa kwei-plasma prekallikrein(KLKB1 mRNA). Abacwaningi basebenzisa i-Donidalorsen ukuhlola izindlela zokuthulisa izakhi zofuzo, i-pharmacokinetics encike kumthamo, kanye nokulawulwa kwesikhathi eside kokuvuvukala okuhambisana ne-bradykinin.
-
I-Fitusiran
I-Fitusiran API iyi-RNA encane ephazamisayo (siRNA) ephenywa ngokuyinhloko emkhakheni we-hemophilia kanye nokuphazamiseka kwe-coagulation. Ihlose ii-antithrombin (AT noma i-SERPINC1)isakhi sofuzo esibindini ukunciphisa ukukhiqizwa kwe-antithrombin. Abacwaningi basebenzisa i-Fitusiran ukuhlola izindlela zokuphazanyiswa kwe-RNA (i-RNAi), ukuthulisa izakhi zofuzo ezithize esibindini, kanye namasu anoveli okwelapha okubuyisela ukulinganisa ukuhlangana ezigulini ze-hemophilia A no-B, ezinama-inhibitors noma ngaphandle kwazo.
-
Givosiran
I-Givosiran API iyi-RNA encane ephazamisayo yokwenziwa (siRNA) efundelwe ukwelashwa kwe-acute hepatic porphyria (AHP). Iqondise ngokuqondile i-I-ALAS1isakhi sofuzo (i-aminolevulinic acid synthase 1), ehilelekile endleleni ye-heme biosynthesis. Abacwaningi basebenzisa i-Givosiran ukuze baphenye izindlela zokwelapha ezisekelwe ku-RNA (RNAi), ukuthulisa izakhi zofuzo eziqondiswe esibindini, kanye nokuguqulwa kwemizila ye-metabolic ehilelekile ku-porphyria kanye nokuphazamiseka kofuzo okuhlobene.
-
I-Plozasiran
I-Plozasiran API i-RNA encane ephazamisayo yokwenziwa (i-siRNA) eyenzelwe ukwelapha i-hypertriglyceridemia kanye nokuphazamiseka kwenhliziyo nemithambo yegazi okuhlobene. Ihlose iI-APOC3I-gene, ehlanganisa i-apolipoprotein C-III, isilawuli esiyinhloko se-triglyceride metabolism. Ocwaningweni, i-Plozasiran isetshenziselwa ukutadisha amasu okwehlisa i-lipid asuselwa ku-RNAi, ukucaciswa kokuthulisa izakhi zofuzo, kanye nokwelashwa okuthatha isikhathi eside ezimeni ezifana ne-familia chylomicronemia syndrome (FCS) kanye ne-dyslipidemia exubile.
-
Zilebesiran
I-Zilebesiran API iyi-RNA encane ephazamisayo yophenyo (siRNA) eyenzelwe ukwelapha umfutho wegazi ophakeme. Ihlose iI-AGTisakhi sofuzo, esihlanganisa i-angiotensinogen—ingxenye eyinhloko yesistimu ye-renin-angiotensin-aldosterone (RAAS). Ocwaningweni, i-Zilebesiran isetshenziselwa ukutadisha izindlela zokuthulisa izakhi zofuzo zokulawula umfutho wegazi wesikhathi eside, ubuchwepheshe bokulethwa kwe-RNAi, kanye nendima ebanzi yomzila we-RAAS ezifweni zenhliziyo nemithambo yegazi.
-
I-Caspofungin yezifo ze-Antifungal
Igama: Caspofungin
Inombolo ye-CAS: 162808-62-0
Ifomula yemolekyuli: C52H88N10O15
Isisindo se-molecule: 1093.31
Inombolo ye-EINECS: 1806241-263-5
Indawo yokubilisa: 1408.1±65.0 °C (Kubikezelwe)
Ukuminyana: 1.36±0.1 g/cm3(Kubikezelwe)
I-acidity coefficient: (pKa) 9.86±0.26 (Kubikezelwe)