I-Retatrutide iyi-agonist ekhulayo yama-multi-receptor, ikakhulukazi esetshenziselwa ukwelapha ukukhuluphala kanye nezifo ze-metabolic. Ingavula ngasikhathi sinye ama-incretin receptors amathathu, okuhlanganisa i-GLP-1 (glucagon-like peptide-1), GIP (insulinotropic polypeptide encike kuglucose) kanye ne-glucagon receptor. Le nqubo eminingi yenza i-retatrutide ibonise amandla amakhulu ekulawuleni isisindo, ukulawula ushukela wegazi kanye nempilo yonke ye-metabolic.
Izici eziyinhloko kanye nemiphumela ye-retatrutide:
1. Izindlela eziningi zokwenza:
(1) I-GLP-1 receptor agonism: I-Retatrutide ithuthukisa ukukhiqizwa kwe-insulin futhi ivimbele ukukhululwa kweglucagon ngokwenza kusebenze ama-GLP-1 receptors, ngaleyo ndlela isize ekwehliseni ushukela wegazi, ibambezele ukuphuma kwesisu futhi yehlise isifiso sokudla.
(2) I-GIP receptor agonism: I-GIP receptor agonism ingathuthukisa ukukhiqizwa kwe-insulin futhi isize ngokuqhubekayo ukwehlisa ushukela wegazi.
2. I-Glucagon receptor agonism: I-Glucagon receptor agonism ingakhuthaza ukubola kwamafutha kanye ne-metabolism yamandla, ngaleyo ndlela isize ekunciphiseni isisindo.
3. Umphumela obalulekile wokulahlekelwa isisindo: I-Retaglutide ibonise imiphumela ebalulekile yokulahlekelwa isisindo ezifundweni zomtholampilo futhi ifaneleka ikakhulukazi iziguli ezikhuluphele noma iziguli ezine-metabolic syndrome. Ngenxa yezindlela zayo eziningi zokwenza, inokusebenza okuvelele ekunciphiseni amafutha omzimba nokulawula isisindo.
4. Ukulawula ushukela wegazi: I-Retaglutide inganciphisa ngempumelelo amazinga kashukela egazini futhi ifaneleka ngokukhethekile iziguli ezinesifo sikashukela sohlobo lwe-2 ezidinga ukulawula ushukela wegazi. Kungasiza ekuthuthukiseni ukuzwela kwe-insulin futhi kunciphise ukushintshashintsha kokushukela wegazi kwangemva kokudla.
5. Amandla empilo yenhliziyo nemithambo yegazi: Nakuba i-retaglutide isesigabeni socwaningo lomtholampilo, idatha yasekuqaleni ibonisa ukuthi ingase ibe namandla okunciphisa ubungozi bezehlakalo zenhliziyo nemithambo yegazi, efana nokuvikelwa kwenhliziyo nemithambo yeminye imithi ye-GLP-1.
6. Ukulawulwa komjovo: I-Retaglutide okwamanje ilawulwa umjovo ongaphansi kwesikhumba, ngokuvamile njengokubunjwa kwesikhathi eside kanye ngesonto, futhi le mvamisa ye-dosing isiza ukuthuthukisa ukuthobela kwesiguli.
7. Imiphumela engemihle: Imiphumela engemihle evamile ihlanganisa izimpawu zesisu esinjengokucanuzela kwenhliziyo, ukuhlanza kanye nesifo sohudo, ezifana nemiphumela engemihle yezinye izidakamizwa ze-GLP-1. Lezi zimpawu zivame kakhulu ezigabeni zokuqala zokwelashwa, kodwa iziguli zivame ukujwayela kancane kancane njengoba isikhathi sokwelashwa sikhula.
Ucwaningo lomtholampilo kanye nokusetshenziswa:
I-Retaglutide isahlolwa ngezinga elikhulu lomtholampilo, ikakhulukazi ukuhlola imiphumela yayo yesikhathi eside nokuphepha ekwelapheni ukukhuluphala. Imiphumela yangaphambi kwesikhathi yokuhlolwa komtholampilo ibonisa ukuthi umuthi unomthelela omkhulu ekwehleni kwesisindo kanye nempilo ethuthukisiwe ye-metabolic, ikakhulukazi ezigulini ezinemiphumela elinganiselwe yemithi yendabuko.
I-Retaglutide ithathwa njengohlobo olusha lomuthi we-peptide onamandla amakhulu wokusebenzisa ekwelapheni ukukhuluphala, i-metabolic syndrome kanye nesifo sikashukela sohlobo 2. Ngokushicilelwa kwedatha eyengeziwe yesilingo somtholampilo esikhathini esizayo, kulindeleke ukuthi kube omunye umuthi ophumelelayo wokwelapha ukukhuluphala kanye nezifo ze-metabolic.
Isikhathi sokuthumela: May-27-2025