Yini i-monjaro (i-tirzepatide)?

I-Mounijaro (i-TirzePatide) iyisidakamizwa sokunciphisa umzimba kanye nokugcinwa okuqukethe i-tirezepatide esebenzayo ye-tirezepatide. I-TirzePatide yi-GIP ebambekayo esebenza isikhathi eside ne-glp-1 receptor agonist. Zombili izithonjana zitholakala ku-pancreatic alpha namaseli we-beta endocrine, inhliziyo, imithambo yegazi, amaseli omzimba (ama-leukocytes), amathumbu nezinso. Ama-GIP Receptors nawo atholakala kuma-adipocyte.
Ngaphezu kwalokho, zombili izithonjana ze-GIP ne-GLP-1 zivezwa ezifundeni zobuchopho ezibalulekile kwisitho se-Appetite. I-TirzePatide ikhetha kakhulu i-GIP yomuntu kanye nama-glp-1 receptors. I-TirzePatide inobudlelwano obuphezulu kubo bobabili i-GIP ne-GLP-1 Receptors. Umsebenzi weTirzepatide e-GIP Receptors uyafana naleso ye-GIP Hormone yemvelo. Umsebenzi weTirzepatide ku-GLP-1 Receptors uphansi kunalokho kwe-glp-1 hormone yemvelo.
I-Mounijaro (i-TirzePatide) isebenza ngokwenza ama-receptors ebuchosheni abalawula isifiso sokudla, okwenza uzizwe ugcwele, ulambile kangako, futhi mancane amathuba okufisa ukudla. Lokhu kuzokusiza udle okuncane futhi wehlise isisindo.
I-Mounjaro kufanele isetshenziswe ngohlelo lokudla okuncishisiwe lwe-calorie kanye nokwenyuka kokusebenza komzimba.

Izindlela zokufaka

I-Mounijaro (i-TirzePatide) ikhonjiswa ngokuphathwa kwesisindo, kufaka phakathi ukunciphisa umzimba kanye nokugcinwa, njengesifinyezo ekudleni okuncishisiwe kwekhalori nokukhulisa umzimba kwabantu abadala nge-Index ye-Old Body Mass Index (BMI) ye:
≥ 30 kg / m2 (Obese), noma
≥ kg 27 kg / m2 kuya ku- <30 kg / m2 (okhuluphele) okungenani okungenani okuhlobene nesisindo okufana ne-dysglycemia (i-prediabete noma i-apnea yesifo sikashukela), noma i-dysbensiden 2 imvume yokulala ekwelashweni nokunamathela ekwanele kokudla
Iminyaka eyi-18-75
Uma isiguli sehluleka ukulahlekelwa okungenani ngo-5% wesisindo somzimba waso wokuqala ngemuva kwezinyanga eziyisithupha zokwelashwa, isinqumo sidinga ukwenziwa ukuthi siyaqhubeka nokwelashwa, sicabangela ukubekezela / iphrofayili yengozi yesiguli ngasinye.

UHLELO LOKUGCINA

Umthamo wokuqala we-Tirezepatide ngu-2,5 mg kanye kanye ngeviki. Ngemuva kwamaviki ama-4, umthamo kufanele ukhuphuke uye ku-5 mg kanye kanye ngeviki. Uma kudingeka, umthamo ungandiswa ngo-2,5 mg okungenani amasonto amane ngaphezulu komthamo wamanje.
Imithamo yokulungisa enconyiwe iyi-5, 10, no-15 mg.
Umthamo omkhulu uneminyaka engu-15 mg kanye kanye.

Indlela ye-Dosing

I-Mounijaro (i-TirzePatide) ingahle ilawulwe kanye ngeviki nganoma yisiphi isikhathi sosuku, ngokudla noma ngaphandle kokudla.
Kufanele ifakwe ngokuthobeka esiswini, ithanga noma ingalo engenhla. Indawo yokujova ingashintshwa. Akufanele ifakwe ngokungenamfihlo noma ngenhla.
Uma kudingekile, usuku lwe-dosing masonto onke lungashintshwa inqobo nje uma isikhathi phakathi kwemithamo okungenani izinsuku ezi-3 (> amahora angama-72). Lapho sekukhethiwe usuku olusha lwe-dosing, i-dosing kufanele iqhubeke kanye ngesonto.
Iziguli kufanele zelulekwe ukuthi zifunde imiyalo yokusetshenziswa kwiphakheji faka ngokucophelela ngaphambi kokuthatha umuthi.