Eminyakeni yamuva nje, ama-GLP-1 receptor agonists (GLP-1 RAs) aqhamuke njengomdlali obalulekile ekwelapheni isifo sikashukela nokukhuluphala, abe yingxenye ebalulekile yokulawulwa kwezifo ze-metabolic. Le mithi ayifezi nje indima ebalulekile ekulawulweni kukashukela egazini kodwa futhi ikhombisa imiphumela emangalisayo ekulawulweni kwesisindo nokuvikela inhliziyo. Ngokuthuthuka okuqhubekayo ocwaningweni, izinzuzo zezempilo zemithi ye-GLP-1 ziya ngokuya ziqashelwa futhi zaziswa.
I-GLP-1 iyi-hormone ye-incretin eyenzeka ngokwemvelo ekhishwa amathumbu ngemva kokudla. Ivuselela ukukhiqizwa kwe-insulin, icindezele ukukhululwa kwe-glucagon, futhi ibambezele ukuphuma kwesisu, konke okunomthelela ekulawuleni kangcono ushukela wegazi. Ama-agonists e-GLP-1 receptor, afana ne-semaglutide, i-liraglutide, ne-tirzepatide, athuthukiswa ngokususelwa kulezi zindlela futhi anikeze izinketho zokwelashwa ezisebenzayo ezigulini ezinesifo sikashukela sohlobo 2.
Ngaphandle kokulawulwa kwe-glycemic, imishanguzo ye-GLP-1 ibonise amandla amangalisayo ekwehliseni isisindo. Ngokusebenza ohlelweni lwezinzwa olumaphakathi, banciphisa isifiso sokudla futhi bakhulise ukusutha, okuholela ekwehleni okungokwemvelo kokudla kwama-calorie. Ucwaningo lwezokwelapha lubonise ukuthi iziguli ezisebenzisa izidakamizwa ze-GLP-1 zithola ukuncipha okukhulu kwesisindo ngisho nangesikhathi esifushane, futhi ukusetshenziswa kwesikhathi eside kungaholela ekwehleni kwesisindo somzimba ngo-10% kuye ku-20%. Lokhu akugcini nje ngokuthuthukisa izinga lempilo lilonke kodwa kwehlisa nengozi yezimo ezihlobene nokukhuluphala ngokweqile njenge-hypertension, i-hyperlipidemia, nesifo sesibindi esinamafutha angenalo utshwala.
Okubaluleke nakakhulu, ezinye izidakamizwa ze-GLP-1 zibonise izinzuzo ezithembisayo zenhliziyo. Ucwaningo lubonisa ukuthi ama-agonists e-GLP-1 receptor anganciphisa ubungozi bezehlakalo ezinkulu zenhliziyo nemithambo yegazi, okuhlanganisa ukuhlaselwa yinhliziyo nokushaywa unhlangothi, anikeze ukuvikeleka okwengeziwe ezigulini ezinesifo senhliziyo esikhona noma lezo ezisengozini enkulu. Ngaphezu kwalokho, izifundo zakuqala zihlola ukuthi zingasebenza kanjani ezinkingeni zemizwa njenge-Alzheimer's and Parkinson's disease, nakuba ubufakazi obengeziwe budingeka kulezi zindawo.
Vele, imishanguzo ye-GLP-1 ingase ibe nemiphumela ethile engemihle. Okuvame kakhulu ukungaphatheki kahle emathunjini njengokucanuzela kwenhliziyo, ukuhlanza, kanye nesifo sohudo, ikakhulukazi ekuqaleni kokwelashwa. Nokho, lezi zimpawu ngokuvamile ziyehla ngokuhamba kwesikhathi. Uma isetshenziswa ngaphansi kokuqondisa kodokotela, izidakamizwa ze-GLP-1 ngokuvamile zibhekwa njengephephile futhi zibekezelelwa kahle.
Sengiphetha, ama-agonists e-GLP-1 receptor aguquke ekwelashweni kwesifo sikashukela esingokwesiko aba amathuluzi anamandla okulawulwa okubanzi kwe-metabolic. Abasizi nje kuphela iziguli ukulawula kangcono ushukela wegazi kodwa futhi zinikeza ithemba elisha lokulawula ukukhuluphala nokuvikela impilo yenhliziyo nemithambo yegazi. Njengoba ucwaningo luqhubeka nokuthuthuka, imithi ye-GLP-1 kulindeleke ukuthi idlale indima enkulu nakakhulu esikhathini esizayo sokunakekelwa kwezempilo.
Isikhathi sokuthumela: Jul-11-2025