Eminyakeni yamuva nje, ama-agonists e-GLP-1 receptor akhule ngokushesha esuka ekwelashweni kwesifo sikashukela kuya kumathuluzi okulawula isisindo, aba ngomunye wemikhakha ebukwa kakhulu kwezokwelapha emhlabeni jikelele. Kusukela maphakathi no-2025, lo mfutho awubonisi uphawu lokuhamba kancane. Izikhondlakhondla zemboni u-Eli Lilly kanye noNovo Nordisk babambe iqhaza emqhudelwaneni omkhulu, izinkampani zamakhemisi zaseShayina zanda emazweni omhlaba, futhi izinhloso ezintsha nezinkomba ziyaqhubeka nokuvela. I-GLP-1 ayisesona nje isigaba sezidakamizwa—iguqukela ekubeni inkundla ebanzi yokulawulwa kwezifo ze-metabolic.
I-tirzepatide ka-Eli Lilly ilethe imiphumela emangalisayo ekuhlolweni komtholampilo kwenhliziyo nemithambo yegazi emikhulu, engabonisi nje kuphela ukusebenza okuqinile kushukela osegazini nokwehliswa kwesisindo, kodwa futhi nokuvikela okuphakeme kwenhliziyo nemithambo yegazi. Izingqapheli eziningi zemboni zikubona lokhu njengesiqalo “sejika lesibili lokukhula” lezindlela zokwelapha ze-GLP-1. Ngaleso sikhathi, iNovo Nordisk ibhekene nezivunguvungu—ukuthengisa okuhamba kancane, ukwehla kweholo, kanye noshintsho lobuholi. Umncintiswano osesikhaleni se-GLP-1 usushintshile usuka kokuthi “izimpi ze-blockbuster” waya emjahweni ogcwele we-ecosystem.
Ngaphandle kwemijovo, ipayipi liyahlukahluka. Amafomu okwenziwa ngomlomo, ama-molecule amancane, nenhlanganisela yokwelapha isathuthukiswa yizinkampani eziningi, zonke zihlose ukuthuthukisa ukuthobela kwesiguli nokugqama emakethe egcwele abantu. Ngesikhathi esifanayo, amafemu emithi yaseShayina enza buthule ukuba khona kwawo azwakale, athola izivumelwano zamalayisense zamazwe ngamazwe ezibiza izigidigidi zamaRandi—uphawu lwamandla akhulayo eShayina ekuthuthukisweni kwezidakamizwa ezintsha.
Okubaluleke nakakhulu, izidakamizwa ze-GLP-1 zidlula ukukhuluphala kanye nesifo sikashukela. Izifo zenhliziyo nemithambo yegazi, isifo sesibindi esinamafutha angenalo utshwala (NAFLD), isifo i-Alzheimer's, ukulutheka, kanye nokuphazamiseka kokulala manje kuyaphenywa, kunobufakazi obandayo obuphakamisa amandla okwelapha e-GLP-1 kulezi zindawo. Yize eziningi zalezi zicelo zisasezigabeni zokuqala zomtholampilo, ziheha ukutshalwa kwezimali kocwaningo olubalulekile kanye nenzuzo enkulu.
Kodwa-ke, ukuthandwa okukhulayo kwezindlela zokwelapha ze-GLP-1 kuletha nokukhathazeka ngokuphepha. Imibiko yakamuva exhumanisa ukusetshenziswa kwesikhathi eside kwe-GLP-1 nezinkinga zamazinyo kanye nezimo zemizwa ezingavamile zamehlo iphakamise amafulegi abomvu phakathi komphakathi nabalawuli. Ukulinganisa ukusebenza kahle nokuphepha kuzoba semqoka ekukhuleni okuzinzile kwemboni.
Kuzo zonke izinto ezibhekwayo, i-GLP-1 ayiseyona nje indlela yokwelapha — isiphenduke inkundla yempi emaphakathi emjahweni wokuchaza ikusasa lempilo ye-metabolic. Kusukela ezenzweni ezintsha zesayensi kuya ekuphazanyisweni kwemakethe, kusukela kumafomu amasha okulethwa kuye ezinhlelweni ezibanzi zezifo, i-GLP-1 akuwona nje umuthi—ithuba lokukhiqiza.
Isikhathi sokuthumela: Aug-01-2025