Emphakathini wanamuhla, ukukhuluphala sekuphenduke inselele yezempilo emhlabeni wonke, kanye nokuvela kweI-Retatrutideinikeza ithemba elisha ezigulini ezilwa nesisindo esiningi. I-Retatrutide iyi-aI-agonist yama-receptor amathathuukuqondisaI-GLP-1R, GIPR, kanye ne-GCGR. Le ndlela eyingqayizivele ye-multi-target synergistic ibonisa amandla angavamile okulahlekelwa isisindo.
Ngomshini, i-Retatrutide iyasebenzaI-GLP-1 receptors, ethuthukisa ukukhiqizwa kwe-insulin, icindezela ukukhululwa kwe-glucagon, futhi ilimbezele ukuphuma kwesisu, ngaleyo ndlela kuthuthukise ukusutha nokunciphisa ukudla. Ukusebenza kwayo kweGIP receptorsiphinde ithuthukise ukuzwela kwe-insulin, ilawule i-lipid metabolism, futhi isebenze ngokubambisana ne-GLP-1 ukukhulisa imiphumela yokunciphisa isisindo. Okubaluleke nakakhulu, ukusebenza kwayo kweama-glucagon receptors (GCGR)kwandisa ukusetshenziswa kwamandla, kuthuthukisa ukuvinjelwa kwe-gluconeogenesis kwesibindi, futhi kunciphisa ukunqwabelana kwamafutha esibindi-ndawonye, lezi zindlela zifaka isandla ekwehleni okukhulu kwesisindo.
Ezivivinyweni zomtholampilo, imiphumela yokulahlekelwa isisindo ye-Retatrutide iye yaphawuleka. Ocwaningweni lwamasonto angama-48 lweSigaba 2 somtholampilo, ababambiqhaza abathola umthamo wamasonto onke we-12 mg we-Retatrutide balahlekelwe isilinganiso24.2% wesisindo somzimba wabo-umphumela owedlula kude imithi eminingi yendabuko yokunciphisa isisindo futhi usondela ekusebenzeni kokuhlinzwa kwe-bariatric. Ngaphezu kwalokho, ukulahlekelwa kwesisindo kuyaqhubeka kuthuthukiswa ngokuhamba kwesikhathi; ngeisonto 72, isilinganiso sokunciphisa isisindo sifinyelele cishe28%.
Ngaphandle komphumela wayo onamandla wokunciphisa isisindo, i-Retatrutide iphinde ibonise isithembiso esihle ekuthuthukiseni izinkinga ezihlobene nokukhuluphala. Inganciphisa umfutho wegazi, ithuthukise iphrofayili ye-lipid, yehlise amazinga e-triglyceride, futhi inikeze isivikelo senhliziyo nemithambo yegazi—kuletheizinzuzo zezempilo eziphelelekubantu abaphila nokukhuluphala ngokweqile.
Isikhathi sokuthumela: Jul-16-2025