I-Retatrutide: Inkanyezi Ekhulayo Engaguqula Ukukhuluphala Nokwelashwa Kwesifo Sikashukela

Eminyakeni yamuva nje, ukukhuphuka kwezidakamizwa ze-GLP-1 ezifana ne-semaglutide ne-tirzepatide kufakazele ukuthi ukwehla kwesisindo esikhulu kungenzeka ngaphandle kokuhlinzwa. Manje,I-Retatrutide, i-agonist yama-receptor kathathu eyakhiwe ngu-Eli Lilly, idonsa ukunaka komhlaba wonke emphakathini wezokwelapha nakubatshalizimali ngokufanayo ngenxa yamandla ayo okuletha imiphumela emikhulu nakakhulu ngokusebenzisa indlela eyingqayizivele yokwenza.

I-Breakthrough Multi-Target Mechanism

I-Retatrutide igqamile ngayoukusebenza kanyekanye kwama-receptors amathathu:

• I-GLP-1 receptor- Yehlisa isifiso sokudla, yehlisa ukuphuma kwesisu, futhi ithuthukisa ukukhiqizwa kwe-insulin

• I-GIP receptor- Ngaphezu kwalokho kuthuthukisa ukukhululwa kwe-insulin futhi kuthuthukisa i-glucose metabolism

• I-Glucagon receptor- Yandisa izinga le-basal metabolic, ikhuthaza ukuwohloka kwamafutha, futhi ikhuphule ukusetshenziswa kwamandla

Le ndlela “yesenzo esiphindwe kathathu” ayisekeli nje kuphela ukwehla kwesisindo esiningi kodwa futhi ithuthukisa izici eziningi zempilo ye-metabolic, okuhlanganisa nokulawulwa kwe-glucose, amaphrofayili e-lipid, nokunciphisa amafutha esibindi.

Imiphumela Emihle Yomtholampilo Yakuqala

Ezivivinyweni zokuqala zemitholampilo, abantu abangewona isifo sikashukela abakhuluphele abathatha i-Retatrutide cishe amasonto angama-48 babona.ukuncipha kwesisindo okumaphakathi okungaphezu kuka-20%, nabanye ababambiqhaza abafinyelela cishe u-24%—ukusondela ekusebenzeni kokuhlinzwa kwe-bariatric. Kubantu abanesifo sikashukela sohlobo 2, umuthi awugcinanga ngokunciphisa kakhulu amazinga e-HbA1c kodwa futhi ubonise amandla okuthuthukisa izici eziyingozi zenhliziyo nemithambo yegazi.

Amathuba Nezinselele Ezingaphambili

Nakuba i-Retatrutide ibonisa isithembiso esimangalisayo, isesigabeni sesi-3 sokuhlolwa komtholampilo futhi mancane amathuba okuba ifinyelele emakethe ngaphambili.2026–2027. Ukuthi ingaba ngempela yini “ushintsho lwegeyimu” kuzoncika kulokhu:

1. Ukuphepha kwesikhathi eside- Ukuqapha imiphumela emibi emisha noma ekhulisiwe uma kuqhathaniswa nemithi ekhona ye-GLP-1

2. Ukubekezelelana nokubambelela- Ukunquma ukuthi ukusebenza kahle okuphezulu kuza ngezindleko zamazinga aphezulu okuyeka

3. Ukusebenza kwezohwebo- Intengo, ukufakwa komshwalense, kanye nokwehlukaniswa okucacile emikhiqizweni encintisanayo

Umthelela Wemakethe Ongaba khona

Uma i-Retatrutide ingakwazi ukulingana phakathi kokuphepha, ukusebenza kahle, kanye nokukwazi ukukhokhela izindleko zayo, ingasetha indinganiso entsha yemithi yokwehlisa isisindo futhi icindezele ukukhuluphala kanye nokwelashwa kwesifo sikashukela enkathiniukungenelela kokunemba okuhlosiwe okuningi- ngokunokwenzeka ukulungisa kabusha yonke imakethe yezifo ze-metabolic.