I-GH / IGF-1 yehla ngokomzimba ngeminyaka, futhi lezi zinguquko zihambisana nokukhathala, i-atrophy yemisipha, ukukhuphuka kwezicubu ze-adipose, nokuwohloka kwengqondo kubantu asebekhulile ...
Ngo-1990, uRudman wanyathelisa iphepha e-New England Journal ye-Medicine ethukile umphakathi - "ukusetshenziswa kwe-hormone yabantu ekhulayo kubantu abangaphezu kweminyaka yobudala engama-60. URudman ukhethe amadoda ayi-12 aneminyaka engama-61-81 ezivivinyweni zemitholampilo:
Ngemuva kwezinyanga eziyi-6 zomjovo we-HGH, izifundo zibe nokwanda okuphakathi kwama-8.8% ku-Music Mass, ama-14.4% ekulahlekelweni kwamafutha, ama-19,1% ku-slensity yesikhumba, ama-17% esigabeni samathambo aqhathaniswa neqembu elidala labantu asebekhulile. I-%, yaphethwa ngokuthi izinguquko ezifuywayo kuzo zonke izifundo zaziyiminyaka eyi-10 kuye kwayi-20.
Lesi siphetho siholele ekuphakamiseni okubanzi kwe-hormone yokukhula kwabantu kabusha (i-rygh) njengomuthi olwa nokuguga, futhi futhi kuyimbangela yenkolelo yabantu abaningi yokuthi umjovo we-rygh angaguga angaguga. Kusukela lapho, odokotela abaningi basebenzise i-HGH njengesidakamizwa esidala, yize singavunyelwe yi-FDA.
Kodwa-ke, njengoba ucwaningo luyaqhubeka nokujula, ososayensi bathole ukuthi izinzuzo ezincane emzimbeni zokwandisa umsebenzi we-GH / IGF-1 azenzile impilo yabantu asebekhulile, kodwa esikhundleni salokho zibeka izingozi zempilo zempilo:
I-Mice Oversecreting GH ingaba yi-30% -40% yokuphila emfushane kunezinguquko ze-Mild-Type MICE [2], i-Glomerulogical Guqula (Glomerulosteosis kanye ne-Hepatocyte Proliferation) zenzeka ngamazinga aphakeme. ezinkulu) kanye nokumelana kwe-insulin.
Izinga eliphakeme le-GH livusa ukukhula kwemisipha, amathambo, nezitho zangaphakathi, okuholela ekugugu (ezinganeni) kanye ne-acromegaly (kubantu abadala). Abantu abadala abane-GH eyeqile bavame ukuhlotshaniswa nezifo sikashukela nezinkinga zenhliziyo, kanye nengozi ephezulu yomdlavuza.
Isikhathi Seposi: Jul-22-2022