Ingabe i-hormone yokukhula ihamba kancane noma isheshisa ukuguga?

I-GH/IGF-1 iyancipha ngokomzimba ngokukhula, futhi lezi zinguquko zihambisana nokukhathala, i-muscle atrophy, ukwanda kwezicubu ze-adipose, nokuwohloka komqondo kubantu asebekhulile...

Ku-1990, uRudman washicilela iphepha ku-New England Journal of Medicine eyashaqisa umphakathi wezokwelapha - "Ukusetshenziswa Kwe-Human Growth Hormone Kubantu Abaneminyaka Engaphezu Kwe-60". U-Rudman ukhethe amadoda angu-12 aneminyaka engu-61-81 ezivivinyweni zomtholampilo:

Ngemuva kwezinyanga ze-6 zomjovo we-hGH, izifundo zibe nokunyuka okujwayelekile kwe-8.8% ku-muscle mass, i-14.4% ekulahlekelweni kwamafutha, i-7.11% esikhumbeni sokuqina kwesikhumba, i-1.6% emathanjeni amathambo, i-19% esibindi kanye ne-17% ku-spleen uma kuqhathaniswa neqembu lokulawula labanye abantu asebekhulile abaneminyaka efanayo. %, kwaphetha ngokuthi izinguquko ze-histological kuzo zonke izifundo zazincane ngeminyaka eyi-10 kuye kwengama-20.

Lesi siphetho siholele ekugqugquzelweni okusabalele kwe-hormone yokukhula komuntu (i-rhGH) njengesidakamizwa esilwa nokuguga, futhi futhi kuyimbangela yenkolelo yabantu abaningi yokuthi umjovo we-rhGH ungavimbela ukuguga. Kusukela lapho, odokotela abaningi baye basebenzisa i-hGH njengesidakamizwa esilwa nokuguga, nakuba singagunyazwanga yi-FDA.

Kodwa-ke, njengoba ucwaningo luqhubeka nokujula, ososayensi bathole ukuthi izinzuzo ezincane emzimbeni zokwandisa umsebenzi we-GH/IGF-1 axis empeleni azikwendisi isikhathi sokuphila kwabantu asebekhulile, kodwa kunalokho zibeka engcupheni yezempilo:

Amagundane adlula i-GH makhulu, kodwa anokuphila okufushane okungu-30% -40% kunamagundane ohlobo lwasendle [2], futhi izinguquko ze-histopathological (glomerulosclerosis kanye nokwanda kwe-hepatocyte) zenzeka kumagundane anamazinga e-GH aphakeme. ezinkulu) kanye nokumelana ne-insulin.

Amazinga aphezulu e-GH akhuthaza ukukhula kwemisipha, amathambo, nezitho zangaphakathi, okuholela ku-gigantism (ezinganeni) kanye ne-acromegaly (kubantu abadala). Abantu abadala abane-GH eyeqile bavame ukuhlotshaniswa nesifo sikashukela nezinkinga zenhliziyo, kanye nengozi enkulu yomdlavuza.