I-Melanotan II

I-Melanotan II API

I-Melanotan IIi-synthetic cyclic heptapeptide analog ofi-α-melanocyte-stimulating hormone (α-MSH), ithuthukiswe ukuzeukuvuselela i-melanogenesis, thuthukisaUkuvikelwa kwe-UV, futhi ulungiseimisebenzi yocansi kanye ne-metabolic. Isebenza njenge-ai-agonist engakhethiama-melanocortin receptors, ikakhulukaziI-MC1R, I-MC3R, futhiI-MC4R.

Ekuqaleni wafundelwa yayoukushukafuthii-photoprotectiveizakhiwo, i-Melanotan II nayo ibonise imiphumela kuukuthuthukiswa kwe-libido, ukucindezela ukudla, futhiibhalansi yamandla, okuyenza ibe i-peptide yocwaningo esebenzayo enentshisekelo ku-dermatology, i-endocrinology, kanye nemithi yocansi.

Indlela Yokwenza

I-Melanotan II isebenza ngokuvula ama-melanocortin receptors amaningana:

• I-MC1R: Kuyashukumisaukukhiqizwa kwe-melanin→ kwandisa umbala wesikhumba kanye nokuvikelwa kwe-UV

• I-MC3R/MC4R: Uhileleke kuukulawula ukudla, ukuthuthukiswa kwe-libido, futhiamandla homeostasis

• Weqa umgoqo wegazi nobuchopho, okuthonya izindlela ezimaphakathi ze-neurohormonal

Ucwaningo Nezicelo Ezingenzeka

Nakuba ingavunyelwe ukusetshenziswa kwezokwelapha, i-Melanotan II ifundelwa kabanzi ngalokhu okulandelayo:

1. Ukushintsha umbala wesikhumba kanye nokuvikelwa kwe-UV

• Iyakhuthazai-eumelanin synthesis, okuholela kuukushuka kwemvelo

• Ihlinzekaimiphumela yokuvikela isithombengaphandle kokuchayeka elangeni

• Amathuba okunciphisa ingozi yomdlavuza wesikhumba kubantu abanebala elimhlophe

2. Ukungasebenzi Kwezocansi

• Kuboniswa kuukwandisa i-libido kanye nokuvusa inkanuko yocansikokubili amadoda nabesifazane

• Ifundelwe njengendlela yokwelapha engaba khonaukungasebenzi kahle kwe-erectile (ED)ngokuvula i-MC4R

3. Ukudla & Ukulawulwa Kwesisindo

• Meyiukunciphisa isifiso sokudla kanye nokudlangokusebenza ezindleleni ze-hypothalamic

• Isengezo esingaba khonaucwaningo lokukhuluphala

Izici ze-API (nge-Gentolex Group)

• Ukuhlanzeka okuphezulu ≥ 99%(I-HPLC ne-LC-MS iqinisekisiwe)

• Kuhlanganiswe ngei-solid-phase peptide synthesis (SPPS)

• I-endotoxin ephansi, izincibilikisi eziyinsalela ephansi

• Itholakala kuI-R&D kuya esikalini sezentengiso