I-L-Carnitine ukusiza ukuhambisa ama-acid amataku amade amade wamandla wamandla

Umsebenzi we-physiological kanye nendima

I-L-Carnitine nayo inomphumela othile wokukhuthaza ekusetshenzisweni komzimba we-KETONE kanye ne-nitrogen metabolism.

1 Kuyaziwa ukuthi noma ama-acid ama-fatty ama-fatty noma ama-acyl-coa angangena ngaphakathi kolwelwesi lwangaphakathi lwe-mitochondrial, kepha i-acylcarnitine ingadlula ngokushesha kulolu membrane, ngaleyo ndlela iqinisekisa ukuthi i-l-carnitine isusa ama-acid ama-membrane avela ngaphandle kokungaphakathi kwe-membrane. Indlela enemininingwane yalokhu ezokuthutha ayicaci, kepha kuqinisekile ukuthi iCarnitineacyl-Coatransferase (Carnitineacyl-Coatransferese) iyinzyme ebalulekile kule nqubo. Abanye abantu bacabanga ukuthi i-l-carnitine nayo ingabamba iqhaza kwezokuthutha kanye ne-excretion kwamanye amaqembu a-acyl, ngakho-ke kungavimba umzimba ubuthi obubangelwa ubuthi be-metabolic ababangelwa ukuqongelela amaqembu athile anama-acino ane-chain.

2 Ucwaningo lwabesilisa abadala abangama-30 lubonisa ukuthi isibalo namandla wesidoda alingana ngqo nokunikezwa kwe-L-Carnitine ekudleni okukhona, futhi okuqukethwe yi-L-Carnitine esiqwini kuhlobene nokuqukethwe kwe-L-Carnitine ekudleni.

3. Thuthukisa ukubekezelelana kwe-watanabe yomzimba et al. uthole ukuthi i-l-carnitine ingathuthukisa ukubekezelela iziguli ezinezifo ngesikhathi sokuzivocavoca, njengesikhathi sokuzivocavoca, umkhawulo wokufakwa kwe-oxygen, i-l-carnitine, kuzoba nezinye izinkomba emzimbeni ngemuva kokuthuthuka; I-Oral L-Carnitine ingaphinde yandise ukubekezelela izicubu zomzimba ngesikhathi sokutholwa kwe-oxygen ephezulu ngo-80%, kufinyeza isikhathi sokutakula ngemuva kokuzivocavoca okunzima, futhi kunciphise ukungezwani nokukhathala okubangelwe ukuzivocavoca. Santulli et al. Kutholakala ngo-1986 ukuthi i-L-Carnitine ingakhuphula izinga lokukhula lokubopha ama-perch culivu futhi linciphise okuqukethwe kwe-cholesterol kanye ne-triglyceride kuzicubu zezinhlanzi. IJalimane ibike ukuthi ngemuva kokuthatha i-l-carnitine amasonto ama-3, okuqukethwe amanoni omzimba abasubathi kwehle kakhulu, futhi ingxenye yamaprotheni yanda, kepha isisindo somzimba asithintekanga.