I-Inclisiran sodium

I-Inclisiran Sodium (API)

Isicelo socwaningo:
I-Inclisiran sodium API (I-Active Pharmaceutical Ingredient) ifundwa ngokuyinhloko emkhakheni we-RNA interference (RNAi) kanye nokwelapha kwenhliziyo nemithambo yegazi. Njenge-siRNA enemicu ephindwe kabili eqondise isakhi sofuzo se-PCSK9, isetshenziswa ocwaningweni lwangaphambi kwezempilo nolwezempilo ukuze kuhlolwe amasu asebenza isikhathi eside okuthulisa ufuzo okwehlisa i-LDL-C (low-density lipoprotein cholesterol). Iphinde isebenze njengenhlanganisela yemodeli yokuphenya izinhlelo zokulethwa kwe-siRNA, ukuzinza, kanye nemithi yokwelapha ye-RNA eqondiswe esibindini.

Umsebenzi:
I-Inclisiran sodium API isebenza ngokuthulisa isakhi sofuzo se-PCSK9 kuma-hepatocyte, okuholela ekwehleni kokukhiqizwa kwephrotheni ye-PCSK9. Lokhu kubangela ukugaywa kabusha okuthuthukisiwe kwama-receptors e-LDL kanye nokucaciswa okukhulu kwe-cholesterol ye-LDL egazini. Umsebenzi wayo njenge-ejenti esebenza isikhathi eside yokwehlisa i-cholesterol isekela ukusetshenziswa kwayo ekwelapheni i-hypercholesterolemia nokunciphisa ingozi yesifo senhliziyo. Njenge-API, yakha ingxenye esebenzayo eyinhloko ekwakhiweni kwezidakamizwa okusekelwe ku-Inclisiran.