I-Etelcalcetide Hydrochloride

I-Etelcalcetide Hydrochloride API
I-Etelcalcetide Hydrochloride iyinoveli yokwenziwa ye-peptide calcimimetic eyenzelwe ukwelapha i-hyperparathyroidism yesibili (SHPT) ezigulini ezinesifo sezinso esingamahlalakhona (CKD) ezithola i-hemodialysis. I-SHPT iyinkinga evamile futhi engathi sína ezigulini ezine-CKD, ebonakala ngamazinga aphezulu e-hormone ye-parathyroid (PTH), ukuphazamisa i-calcium-phosphate metabolism, kanye nengozi eyandayo yesifo samathambo nesifo senhliziyo.

I-Etelcalcetide imele i-calcimimetic yesizukulwane sesibili, elawulwa ngomthambo, futhi inikeza izinzuzo ngaphezu kwemithi yokwelapha yomlomo yangaphambilini njenge-cinacalcet ngokuthuthukisa ukuthobela kanye nokunciphisa imiphumela emibi yesisu.

Indlela Yokwenza
I-Etelcalcetide isebenza ngokubopha nokusebenzisa i-calcium-sensing receptor (CaSR) etholakala kumaseli e-parathyroid gland. Lokhu kulingisa umphumela wokuphila we-calcium engaphandle kweseli, okuholela ku:

Ukunciphisa ukukhiqizwa kwe-PTH

Ukunciphisa izinga le-calcium ne-phosphate serum

Ukuthuthukiswa kwebhalansi yamaminerali kanye ne-bone metabolism

Njenge-activator ye-allosteric esekelwe ku-peptide ye-CaSR, i-Etelcalcetide ibonisa ukucaciswa okuphezulu nomsebenzi oqhubekayo kulandela ukuphathwa kwe-intravenous post-dialysis.

Ucwaningo Lwezempilo kanye Nomphumela Wokwelapha
I-Etelcalcetide iye yahlolwa kabanzi esigabeni sesi-3 sokuhlolwa komtholampilo, okuhlanganisa izifundo ze-EVOLVE, AMPLIFY, kanye ne-EQUIP. Okutholakele okubalulekile kuhlanganisa:

Ukwehliswa okuphawulekayo nokuqhubekayo kumazinga e-PTH ezigulini ze-CKD ku-hemodialysis

Ukulawulwa okusebenzayo kwe-serum calcium ne-phosphorus, okunikela ekuthuthukisweni kwe-homeostasis yamathambo namaminerali

Ukubekezelelana okungcono uma kuqhathaniswa ne-calcimimetics yomlomo (i-nausea encane nokuhlanza)

Ukubambelela okuthuthukisiwe kwesiguli ngenxa yokuphathwa kwe-IV kwamasonto amathathu phakathi neseshini ye-dialysis

Lezi zinzuzo zenza i-Etelcalcetide ibe inketho yokwelapha ebalulekile yama-nephrologists aphatha i-SHPT kuzibalo ze-dialysis.

Ikhwalithi Nokukhiqiza
I-Etelcalcetide Hydrochloride API yethu:

Ihlanganiswa nge-solid-phase peptide synthesis (SPPS) enobumsulwa obuphezulu

Ivumelana nezicaciso zebanga lezemithi, ezifanele ukwakheka komjovo

Ibonisa amazinga aphansi ezincibilikisi eziyinsalela, ukungcola, nama-endotoxins

Ingalinganiswa ekukhiqizweni kwenqwaba enkulu ethobelana ne-GMP