I-Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Incazelo emfushane:

I-Boc-His(Trt)-Aib-Gln(Trt)-Gly-OHiyi-tetrapeptide evikelwe esetshenziswa ku-peptide synthesis kanye nezifundo zesakhiwo. Iqembu le-Boc (tert-butyloxycarbonyl) livikela i-N-terminus, kuyilapho amaqembu e-Trt (trityl) avikela amaketanga aseceleni e-histidine ne-glutamine ukuze avimbele ukusabela okungafunwa. Ukuba khona kwe-Aib (α-aminoisobutyric acid) kukhuthaza ukuhlangana kwe-helical futhi kuthuthukise ukuzinza kwe-peptide. Le peptide ibalulekile ekuphenyeni ukugoqeka kwe-peptide, ukuzinza, nanjengesikafula sokuklama ama-peptide asebenza ngokwebhayoloji.

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I-Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH

Isicelo socwaningo:
Le tetrapeptide evikelwe isetshenziswa ku-peptide synthesis kanye nezifundo ezihambisanayo. Ukufakwa kwe-Aib (α-aminoisobutyric acid) kuvumela abacwaningi ukuthi baphenye izakhiwo ze-helical nokuziphatha okugoqa kuma-peptide amafushane. Amaqembu asebenzayo avikelwe (Boc, Trt) aqinisekisa ukuzinza nokukhetha ngesikhathi sokuhlanganiswa kwe-peptide yesigaba esiqinile, okuyenza ibe imodeli ebalulekile yokufunda amandla e-peptide backbone kanye nokusebenzisana kwe-side-chain.

Umsebenzi:
I-Boc-His(Trt)-Aib-Gln(Trt)-Gly-OH isebenza njengenhlanganisela yemodeli yokuhlola ukuzinza kwe-peptide kanye ne-structural motifs. I-Aib isiza ekuqiniseni i-helical, kuyilapho izinsalela ze-histidine ne-glutamine zinikeza amasayithi okusebenzisana okungenzeka, awusizo ekuklameni ama-peptide e-bioactive noma ukulingisa izingcezu zamaprotheni. Kungaba futhi isandulela sama-peptide asebenzayo ekuthuthukisweni kwezidakamizwa noma ekuhlolweni kwamakhemikhali e-biochemical.

Okwedlule: I-Boc-Tyr(tBu)-Aib-Glu(OtBu)-Gly-OH

Olandelayo: I-Fmoc-L-Lys[Ste(OtBu)-γ-Glu-(OtBu)-AEEA-AEEA]-OH

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