AEEA-AEEA

I-AEEA-AEEA (i-Aminoethoxyethoxyacetate dimer)

Isicelo socwaningo:
I-AEEA-AEEA iyi-hydrophilic, i-spacer eguquguqukayo evame ukusetshenziswa ocwaningweni lwe-peptide nokuhlanganiswa kwezidakamizwa. Iqukethe amayunithi amabili asekelwe ku-ethylene glycol, okwenza kube usizo ekutadisheni imiphumela yobude besixhumanisi nokuguquguquka ekusebenzisaneni kwamangqamuzana, ukunyibilika, kanye nomsebenzi webhayoloji. Abacwaningi bavame ukusebenzisa amayunithi e-AEEA ukuhlola ukuthi ama-spacers athonya kanjani ukusebenza kwama-antibody-drug conjugates (ADCs), ama-peptide-drug conjugates, namanye ama-bioconjugates.

Umsebenzi:
I-AEEA-AEEA isebenza njengesixhumi esivumelana ne-biocompatible esithuthukisa ukuncibilika, sehlise isithiyo esiqinile, futhi sithuthukise ukuguquguquka kwamangqamuzana. Isiza ngokuhlukanisa izizinda ezisebenzayo ngaphakathi kwe-molecule, njengokukhomba ama-ligand nemithwalo ekhokhelwayo, okuvumela ukubophezela nomsebenzi osebenza kahle kakhudlwana. Imvelo yayo engeyona i-immunogenic kanye ne-hydrophilic nayo ifaka isandla ekuthuthukisweni kwamaphrofayili e-pharmacokinetic ekusetshenzisweni kokwelapha.