I-NAD+ iyi-coenzyme ebalulekile ezinqubweni zempilo yeselula, idlala indima ebalulekile kumetabolism yamandla, ukulungiswa kwe-DNA kanye nokulwa nokuguga, impendulo yokucindezeleka kwamaselula kanye nokulawulwa kwesignali, kanye ne-neuroprotection. Kumetabolism yamandla, i-NAD+ isebenza njengesithwali se-electron ewukhiye ku-glycolysis, umjikelezo we-tricarboxylic acid, kanye ne-mitochondrial oxidative phosphorylation, eqhuba ukuhlanganiswa kwe-ATP kanye nokuphakela amandla emisebenzi yamaselula. Ngasikhathi sinye, i-NAD+ isebenza njenge-substrate ebalulekile yama-enzyme okulungisa i-DNA kanye ne-activator yama-sirtuin, ngaleyo ndlela igcine ukuqina kwe-genomic futhi inikele ekuphileni isikhathi eside. Ngaphansi kwezimo zengcindezi ye-oxidative nokuvuvukala, i-NAD+ ibamba iqhaza ekuboniseni izindlela kanye nokulawulwa kwe-calcium ukuze kugcinwe i-homeostasis yamaselula. Ohlelweni lwezinzwa, i-NAD+ isekela ukusebenza kwe-mitochondrial, inciphisa ukulimala kwe-oxidative, futhi isiza ukubambezela ukuqala nokuqhubeka kwezifo ze-neurodeergenerative. Njengoba amazinga e-NAD+ ehla ngokwemvelo ngenxa yobudala, amasu okugcina noma okuthuthukisa i-NAD+ aya ngokuya aqashelwa njengabalulekile ekukhuthazeni impilo kanye nokunciphisa ukuguga.